O uso clínico e estético da toxina botulínica e seu processo produtivo

Abstract

Since the first cases of botulinum neurotoxin (BoNT) causing damage in humans were documented, this has attracted the interest of researchers who want to understand both the producing microorganism and the structure of the protein and its mechanism of action. The advancement of biotechnological tools has greatly helped in the development of this knowledge, and this neurotoxin, once a villain and a biological warfare, is becoming a therapeutic option for a myriad of neuromuscular pathologies and has recently become worldwide known for its use in aesthetics as an alternative for managing the signs of aging. This research work aims to compile the trajectory of discovery, use, tools used to unveil and manipulate their molecular bases, current perspectives for large-scale production and new applications for BoNT. This work has the main focus on identifying whether there is room for advances in the use of botulinum toxin in the clinic and aesthetics and if the new molecular biology tools through bioengineering bring new perspectives to the production, use and applications of this molecule. This work also aims to outline a path for future research with other toxins and pathogens to trace in the search for solutions for a better quality of life for people.