Desenvolvimento de sistemas para liberação transdérmica de substâncias bioativas

Abstract

In the search for new means of transport and controlled release of bioactive substances systems aimed at minimizing the amount of substance administered, stand-biodegradable polymers. These materials have great versatility, are easily acquired, have physical properties suitable thermal and mechanical. In addition, their nature influence significantly in size and system release profile. Among the most widely used natural polymers, starch excels due to low cost, a natural polymer to be easily metabolized by the body, non-toxic, does not react with other ingredients of the formulation have good viscosity and be biodegradable. In this context, this study aimed to develop films based on pure starch and bioactive substances, naproxenato of Timila and naproxenato of eugenila with different plasticizer content aimed at production of transdermal delivery systems. Thus, we evaluated the thermal, morphological, mechanical, biodegradable and the kinetics of release of the bioactive substance incorporated into the film. The summaries of naproxenatos of eugenila and Timila were successfully carried out. It is expected that the compounds obtained have more potent anti-inflammatory effect that naproxen and exhibit reduced ulcerogenic effect. Starch films with different glycerol levels presented to translucent and good plasticity. The results obtained for transparency, flexibility and solvent evaporation of time varied with the amount of glycerin used, and the best results the film containing 8% (w / w) glycerin. The micrographs showed films with smooth surface, indicating uniform and dense films, and some films showed homogeneous surface with glycerine dominoes and small holes. The micrographs of the film with naproxen showed the same characteristics. For controlled release results showed that after one hour of contact with phosphate buffered saline solution was large percentage of naproxen release at maximum steady release up to 50 hours for this film. Moreover, the films with plasticisers and the bioactive substance remain biodegradable. Thus, the results demonstrated that such material has great potential application for transdermal drug delivery systems.