Marcadores moleculares associados a resistência de Klebsiella pneumoniae frente a antimicrobianos: uma revisão de literatura

Abstract

Bacterial resistance against antimicrobials has currently been a subject of extreme interest. Among the most important resistant bacterial species, Klebsiella pneumoniae stands out for causing several hospital infections, such as urinary tract infections, pneumonia, wound infections, liver abscesses, meningitis and bacteremia. Its resistance is associated with the production of carbapenemase (KPC). For diagnosis and research, the use of molecular techniques to detect markers associated with resistance is extremely important. The objective of this work is to perform a literature review with a survey of the main molecular markers for the detection of carbapenemase-producing Klebsiella pneumoniae. This work aims to describe the main molecular markers described in the literature detected by molecular techniques for the identification of resistant strains of Klebsiella pneumoniae. The expectation is that this work will obtain information on the profile of molecular markers expressed in the detection of bacterial resistance of Klebsiella pneumoniae against antimicrobials of choice. So that the information provided can contribute to the area of study, research scope and clinical diagnosis using molecular techniques.