Filmes de celulose bacteriana modificados como curativos que liberam antibiótico

Abstract

Bacterial cellulose is a biomaterial that has the same chemical structure as vegetable cellulose, but is morphologically different. In the medical field, it is used in grafts, healthy skin substitutes and as dressings to treat injuries. By itself, this material does not have antimicrobial properties to prevent the internal growth of generations, requiring additional modifications to incorporate antimicrobial activity. This work presented a preparation of a superficially modified cellulose membrane for use as a biocurative, as well as its capacity for absorption and release of the drug oxacillin. The product of the surface modification was confirmed by infrared spectroscopy. The process of quantifying the absorption of the drug was determined by ultravioletvisible spectrophotometry. The modified membrane presented 3.8% (w/w) of the drug by cellulose mass, while the native membrane did not absorb absorption. The release of the drug was analyzed by ultraviolet spectroscopy, favorable to the application as a wound dressing.