Estudo sobre a modificação da superfície da celulose bacteriana copolimerizada com PNIPAAm via mecanismo ATRP

Abstract

Bacterial cellulose is a natural polymer that due to its biodegradable and biocompatible characteristics, has attracted great interest for studies in the biomedical field. In the field of tissue engineering, research has been developed to create regenerative treatments with drugs based on the use of synthetic and natural polymers. However, the possibility of promoting copolymerization synthesis by conventional methods is not selective due to the difficulty in developing chemical reactions on the surface of this polymer. In this study, the synthesis of copolymerization graftfrom of the thermosensitive polymer N, Npolyisopropylacrylamide (PNIPAAm) was proposed on the surface of the bacterial membrane via atomic transfer radical polymerization mechanism (ATRP), mediated by the Cu (I) complex and the esterified αbromoisobutyrate in bacterial cellulose. The results show that the polymerization conditions work when developed in a homogeneous phase, but there is great difficulty in developing them in a heterogeneous phase.